https://www.primehealthchannel.com/opioid-dependence.html The channel that provides the best solutions for your health problems as well as providing quality health articles! Mon, 08 Apr 2019 12:57:34 +0000 hourly 1 https://wordpress.org/?v=6.0.2 https://www.primehealthchannel.com/opioid-dependence.html#comment-1411991 Wed, 08 Nov 2017 06:41:45 +0000 https://www.primehealthchannel.com/?p=5732#comment-1411991 All drugs of abuse activate dopamine release whether cocaine, opiates , marijuana , smoking or alcohol. New studies with novel dopamine d-1 antagonists are needed to see if what is seen in animals with translate into man. D-1 antagonists may also work synergistically with other medications already used to treat addiction.

]]> https://www.primehealthchannel.com/opioid-dependence.html#comment-1411990 Wed, 08 Nov 2017 06:37:05 +0000 https://www.primehealthchannel.com/?p=5732#comment-1411990 Opiates cause addiction by increasing the release of dopamine. When dopamine is released it activates what are known as dopamine receptors. There is the D-1 and several other types of dopamine receptors. The D-1 receptor appears to be strongly associated with opiate addiction. One approach to prevent opiate addiction would be to administer a D-1 receptor blocker together with an opiate drug to reduce the high and addictive potential. It works in animals but it needs to be studied in humans.ecopipam is a D-1 receptor blocker that appears to be safe and should be tested for preventing opiate addiction.
Examination of the neurochemical substrates mediating the motivational effects of opioids: role of the mesolimbic dopamine system and D-1 vs. D-2 dopamine receptors.J Pharmacol Exp Ther. 1993 Apr;265(1):53-9.

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